Gene tampering based on dud science (23/8/2005)

Critical comments on genetic engineering from a Christian and scientist.

see also: 'GM Crops? A Christian Response',

An agenda on GE for the World Council of Churches

Theory behind gene-tampering
Dr Robert Mann
Dec 2003 - revised Aug 2005

            Not only practising gene-manipulators but also a much wider range of scientists should speak out for much stricter control of gene-tampering because it is based on dud science.

            Prof Richard Strohman has pointed out, in a sporadic small series of articles in Nature Biotechnology, many defects in the Lego model of biology which 'informs' the gene-tampering trade.  Dogma long refuted is crucial among the axioms of the gene-jiggerers, e.g

• "one gene one protein",

• "only 4 letters in the DNA code",

• "randomness becomes utmost precision as we slam in synthetic nucleic acids by weapons-grade biolistics",

• "seen one redwood y' seen 'em all - especially once we've cloned & patented lo-lignin™ sequoia";

• etc etc. 

            The main characteristic of this set of slogans is that they are scientific drivel.  The Schubert Letter (Nat Biotech  Oct 2002 p. 969) would alone serve to refute them. 

            The main general scientific answer is that nature is far from random.  The idea that slapping in  -  randomly !  -  a few genes by radically unnatural processes will have more predictable effects than offering a whole genome of 104- 105genes in cross-pollination is wrong for the main reason that it assumes natural crosses to be random or nearly so.  A top-level affirmation of this assumption was stated by main Monsanto-connected gene-jockeys Roger Beachy et bulk in their (Nat Biotech  Nov 2002) 'enraged' response to the Schubert Letter:-

                             ' The reality is that "unintentional consequences" are much more likely to occur in nature than in biotechnology because nature relies on the unintentional consequences of blind random genetic mutation and rearrangement to produce adaptive phenotypic results, whereas GM technology employs precise, specific, and rationally designed genetic modification toward a specific engineering goal. '

            The immediate response to this furphy is that there's almost nothing random in nature.  We know, admittedly, v little about the natural barriers to error in traditional breeding; that does not prove they're unreal or random.  A gene-jockey of plants, Prof Patrick Brown, has made this & related points at www.psrast.org.

            What is so precise, specific, or rational about GM as done so far?  The answer is, very little indeed.  Its outcomes are inherently unpredictable.  The tiny minority of target cells that both survive and have incorporated somewhere in the genome the desired gene cassette will, in general, also develop other unforeseeable properties, e.g deviant metabolism generating toxins or allergens.

            Indeed, the assertion of Beachy et al. is refuted by the known figures on frequency of unexpected mutations in GM-cells compared with mutation rates from breeding.

            The fundamental general answer however is that nature is extremely orderly.  It is complex, but not like a bowl of alphabet soup; nature   -  especially life  -  is systematic.  This should be agreed by all scientists, even atheists; of course, us theists ascribe the systematic order to design, but those who resist belief in design will, I hope, agree nature to be systematically orderly.  If you think, like Dawkins, that nature is just the result of the outworkings of physics & chemistry, then you could fairly easily assume that even random insertion of 'cassettes' would be no more likely than traditional breeding to cause harm.  If on the other hand you believe (to take a specific case) that an apple is not just a random collection of biochemicals but a creation of a benign Creator, and that Grandmother Smith in a Seedknee suburb was a humble agent of that Creator (selecting a new mutant that had arrived according to His rules), then you will contrast such natural processes with the overwhelming of natural barriers to slam in viral promoters joined onto synthetic approximate copies of bacterial genes by biolistics, or modified T-plasmids - violent processes expected to disrupt the target genome.  Breeding entails natural protections from error which are overwhelmed by gene-tampering.

             I tend to think it is on this level that the issue really turns.  For those who think so, re-reading of Genesis 3  may be salutory.    

            In a culture that has largely turned away from the religion that gave rise to its legal principles, the ethics of gene-tampering is in drastic need of fundamental review.  Gene-jiggering has already sucked in $1011, and still only a few corporations have produced anything saleable (except those selling the enzyme kits etc for the gene-tampering expts).  The science behind this commercial frenzy is junk; the Lego model of biology never looked promising and is now known to be wrong.  Proper biology points to the Schubert Letter, and in response a gaggle of Monsanto stooges intones 'enragedly' the atheistic moronic rubbish quoted above.

            Never in the

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