1.The Ghost in Your Genes
2.Grandad's diet affects descendants' health
The impact of the food experienced by a child could be passed on to subsequent generations.
"...the lives of your grandparents - the air they breathed, the food they ate, even the things they saw can directly affect you, decades later, despite your never experiencing these things yourself. And... what you do in your lifetime could in turn affect your grandchildren."
"We are all guardians of our genome." (item 1)
COMMENT - Claire Robinson, Weekly Watch editor
I hope some of our UK readers caught Thursday's BBC Horizon programme about epigenetics. It showed a bunch of geneticists catching up with what's been obvious to most of us all along: that environmental factors (the programme mentioned severe emotional stress and smoking, though mostly steered clear of the 'hot potato' of manmade environmental pollutants) cause heritable effects in humans.
According to the programme, "The conventional view is that DNA carries all our heritable information and that nothing an individual does in their lifetime will be biologically passed to their children". But epigenetics goes beyond DNA, proposing that environmental factors can switch genes on or off and that the effects are passed down through generations.
Apparently, the news that what we take into our bodies affects our progeny seems so "radical" to these geneticists that at least one of them cannot sleep at night for thinking about the consequences. Could this be the day Western science finally grows up?
1.The Ghost in Your Genes
Biology stands on the brink of a shift in the understanding of inheritance. The discovery of epigenetics hidden influences upon the genes could affect every aspect of our lives.
At the heart of this new field is a simple but contentious idea that genes have a 'memory'. That the lives of your grandparents the air they breathed, the food they ate, even the things they saw can directly affect you, decades later, despite your never experiencing these things yourself. And that what you do in your lifetime could in turn affect your grandchildren.
The conventional view is that DNA carries all our heritable information and that nothing an individual does in their lifetime will be biologically passed to their children. To many scientists, epigenetics amounts to a heresy, calling into question the accepted view of the DNA sequence a cornerstone on which modern biology sits.
Epigenetics adds a whole new layer to genes beyond the DNA. It proposes a control system of 'switches' that turn genes on or off and suggests that things people experience, like nutrition and stress, can control these switches and cause heritable effects in humans.
In a remote town in northern Sweden there is evidence for this radical idea. Lying in Overkalix's parish registries of births and deaths and its detailed harvest records is a secret that confounds traditional scientific thinking. Marcus Pembrey, a Professor of Clinical Genetics at the Institute of Child Health in London, in collaboration with Swedish researcher Lars Olov Bygren, has found evidence in these records of an environmental effect being passed down the generations. They have shown that a famine at critical times in the lives of the grandparents can affect the life expectancy of the grandchildren. This is the first evidence that an environmental effect can be inherited in humans.
In other independent groups around the world, the first hints that there is more to inheritance than just the genes are coming to light. The mechanism by which this extraordinary discovery can be explained is starting to be revealed.
Professor Wolf Reik, at the Babraham Institute in Cambridge, has spent years studying this hidden ghost world. He has found that merely manipulating mice embryos is enough to set off 'switches' that turn genes on or off.
For mothers like Stephanie Mullins, who had her first child by in vitro fertilisation, this has profound implications. It means it is possible that the IVF procedure caused her son Ciaran to be born with Beckwith-Wiedemann Syndrome a rare disorder linked to abnormal gene expression. It has been shown that babies conceived by IVF have a three- to four-fold increased chance of developing this condition.
And Reik's work has gone further, showing that these switches themselves can be inherited. This means that a 'memory' of an event could be passed through generations. A simple environmental effect could switch genes on or off and this change could be inherited.
His research has demonstrated that genes and the environment are not mutually exclusive but are inextricably intertwined, one affecting the other.
The idea that inheritance is not just about which genes you inherit but whether these are switched on or off is a whole new frontier in biology. It raises questions with huge implications, and means the search will be on to find what sort of environmental effects can affect these switches.
After the tragic events of September 11th 2001, Rachel Yehuda, a psychologist at the Mount Sinai School of Medicine in New York, studied the effects of stress on a group of women who were inside or near the World Trade Center and were pregnant at the time. Produced in conjunction with Jonathan Seckl, an Edinburgh doctor, her results suggest that stress effects can pass down generations. Meanwhile research at Washington State University points to toxic effects like exposure to fungicides or pesticides causing biological changes in rats that persist for at least four generations.
This work is at the forefront of a paradigm shift in scientific thinking. It will change the way the causes of disease are viewed, as well as the importance of lifestyles and family relationships. What people do no longer just affects themselves, but can determine the health of their children and grandchildren in decades to come. "We are," as Marcus Pembrey says, "all guardians of our genome.
2.Grandad's diet affects descendants' health
New Scientist, 31 October 2002
The amount of food a boy eats in the years before puberty influences his grandchildren's risk of diabetes, a small Swedish study suggests.
Researchers looked at 303 people, born either in 1890, 1905 or 1920, and the harvest data for the region where they lived. They found that males in areas with a surfeit of food were four times more likely to have grandchildren who died of diabetes mellitus than those who suffered famine in childhood.
"Overeating in the 'slow-growth' period before puberty affects the likelihood of the second generation having diabetes," says lead researcher Gunnar Kaati at Umea University, Sweden. "But we don't know exactly why."
The researchers acknowledge that more research is needed to replicate and explain their results. "But very little attention has been paid to this kind of inheritance, and it is an important subject to look at," Kaati told New Scientist.
Similar effects have been shown in sons and daughters before, but if confirmed, the study would be the first evidence of the effect in grandchildren says geneticist Laurence Hurst at Bath University, UK.
Environmental factors can affect genes by altering the methylation of DNA bases. This changes the expression of the genes concerned. The impact of the nutritional conditions experienced by a child could be passed on to subsequent generations in this way.
In the study, only the paternal grandfather appeared to influence the health of their descendants, although male and female grandchildren were affected equally.
This suggests imprinted genes - whose expression is determined by which parent they were inherited from - may be involved, says Marcus Pembrey at the Institute of Child Health, London, UK. "For example, insulin growth factor 2, which is involved in diabetes, is silenced when transmitted by the mother and active when transmitted by the father," he told New Scientist
Journal reference: European Journal of Human Genetics (DOI: 10.1038/sj.ejhg.5200859)
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